Finding medicines that can kill cancer cells while leaving normal tissue unscathed is a Holy Grail of oncology research. In two new papers, scientists at UC San Francisco and Princeton University present complementary strategies to crack this problem with “smart” cell therapies – living medicines that remain inert unless triggered by combinations of proteins that only ever appear together in cancer cells. Biological aspects of this general approach have been explored for several years in the laboratory of Wendell Lim, PhD, and colleagues in the UCSF Cell Design Initiative and National Cancer Institute-sponsored Center for Synthetic Immunology. But the new work adds a powerful new dimension to this work by combining cutting-edge therapeutic cell engineering with advanced computational methods. For one paper, published Sept. 23, 2020, in s, members of Lim’s lab joined forces with the research group of computer scientist Olga G. Troyanskaya, PhD, of Princeton’s Lewis-Sigler Institute for Integrative Genomics and the Simons Foundation’s Flatiron Institute. Using a machine learning approach, the team analyzed massive databases of thousands of proteins found in both cancer and normal cells. They then combed through millions of possible protein combinations to assemble a catalog of combinations that could be used to precisely target only cancer cells while leaving normal ones alone. In another paper, published in Science on Nov. 27, 2020, Lim and colleagues then showed how this computationally derived protein data could be put to use to drive the design of effective and highly selective cell therapies for cancer. “Currently, most cancer treatments, including CAR T cells, are told ‘block this,’ or ‘kill this,’” said Lim, also professor and chair...
What happened in the Colonial Pipeline ransomware attack Colonial Pipeline, the operator of a major pipeline system that transports fuel across the East Coast said it had been victimized by a ransomware attack and had halted all pipeline operations to deal with the threat. It may seem too late to fill the position now, but Colonial Pipeline, the target of the biggest pipeline hack in history, began searching for a cyber-security manager nearly two months ago. Colonial Pipeline, a Georgia-based oil company, sought someone to manage a team of security experts in order to “develop, validate and maintain an incident response plan and processes to address potential threats.” Job requirements included a bachelor’s degree in computer science, information security or a related field, according to an on Colonial’s website. The job posting also appeared on search sites such as Indeed, ZipRecruiter and GlassDoor. A spokesperson for the company told FOX Business that the position – which has been open for more than 30 days – was not created as a result of the ransomware attack and is part of a broader initiative by the company to “continue building our current cybersecurity team.” “We have several positions open as part of our longer-term growth strategy around talent, as we are constantly recruiting top-tier talent across all functional areas of our business,” the spokesperson added. The ransomware attack crippled North America’s biggest fuel pipeline late last week, cutting off almost half of the gasoline and diesel burned on the nation’s East Coast. Gas stations across several states have run out of fuel amid panic-buying and a lack of supplies. The average...
A new master’s degree in cyber-security and privacy will be offered beginning this fall at UCF, designed to train professionals who can protect and defend computer systems, networks and organizations from costly cyber attacks. The recent ransomware attack that crippled a southeast regional gasoline supply line has called attention to the impact and cost that cyber breaches have on daily life, and illustrates the nation’s critical need for cybersecurity and defense professionals. The number of cyber attacks and data breaches is increasing, costing the U.S. economy more than $110 billion annually according to national estimates, while thousands of cyberdefense jobs remain unfilled. In Florida alone, more than 21,000 cybersecurity jobs are currently available. Nationally, cyber jobs — such as information security analysts — are expected to grow 31% in 10 years, according to the Bureau of Labor Statistics, and the average salary is $103,190. Yan Solihin, the Charles N. Millican Professor of Computer Science, says that the attacks are increasing partly because of the proliferation of connected and networked devices such as smart cars, smart appliances and the “Internet of Things,” and partly because the nation cannot produce skilled cybersecurity professionals fast enough. “We live in a dangerous world and cyber attacks, such as ransomware and phishing, are increasing,” says Solihin. “Hackers are looking at all of the infrastructure that we have. They will keep probing for vulnerabilities which are often found in organizations that do not have enough trained professionals to provide oversight, protection and defense measures.” By offering a master’s degree in cyber security and privacy, Solihin says, UCF is doing its part to produce the talent...
By Andrew Pavliv, Tetiana Boichenko, Max Nechepurenko, Ihar Rubanau • July 05, 2018 Machine learning in finance may work magic, even though there is no magic behind it (well, maybe just a little bit). Still, the success of machine learning project depends more on building efficient infrastructure, collecting suitable datasets, and applying the right algorithms. Machine learning is making significant inroads in the financial services industry. Let’s see why financial companies should care, what solutions they can implement with AI and machine learning, and how exactly they can apply this technology. We can define machine learning (ML) as a subset of data science that uses statistical models to draw insights and make predictions. The chart below explains how AI, data science, and machine learning are related. For the sake of simplicity, we focus on machine learning in this post. The magic about machine learning solutions is that they learn from experience without being explicitly programmed. To put it simply, you need to select the models and feed them with data. The model then automatically adjusts its parameters to improve outcomes. Data scientists train machine learning models with existing datasets and then apply well-trained models to real-life situations. The model runs as a background process and provides results automatically based on how it was trained. Data scientists can retrain models as frequently as required to keep them up-to-date and effective. For instance, our client Mercanto retrains machine learning models every day. In general, the more data you feed, the more accurate are the results. Coincidentally, enormous datasets are very common in the financial services industry. There are petabytes of data on transactions, customers, bills, money transfers, and so on. That is a perfect fit for machine...
Waikato District Health Board’s top boss said no ransom will be paid to cyber security attackers who have targeted its IT services today. Chief executive Kevin Snee told Stuff “no ransom will be paid” and he did not know who was behind the attack. Cyber security expert Bruce Armstrong told the Herald he believes it is a ransomware attack on Waikato DHB from Asia or the Middle East, similar to what has hit the Irish health system in recent days. He believes it is similar in nature to the DDoS attacks that rocked the New Zealand Stock Exchange (NZX) last year and overrun its system for days. “Health organisations are highly prized as targets globally and health industries throughout the world are the most attacked and most expensive type of attacks that happen,” the Darkscope founder said. “The normal pattern is they will warn the organisation they will do it, and run half an hour DDoS attacks, and if the ransom is not paid they will attack at hours at a time. “The attack on the NZX played out over three days before they were able to completely stop its affect on their systems.” He said ransomware attacks are not targeting patient data and the only interest is to get money from the organisation. “It’s purely commercial … they’re just doing it to take money from the organisations that they’re attacking,” Armstrong said. “It’s a game of cat and mouse. Unless defence systems can get better we will see them happening throughout the world.” 17 May, 2021 10:10 PMQuick Read The major cyber security attack has been described as...
The Queen is looking to hire a cyber security expert to protect the Firm’s emails and Google searches from hackers. The Royal Household posted an advertisement for a Cyber Security Engineer, earning between £50,000 and £60,000 and working 37 and a half hours a week. The role will involve monitoring the household’s ‘network and systems’, identifying security threats and leading ‘response activities’. The advert, posted on the royal vacancies website, asks that candidates submit their CVs by May 26, before interviews start in June. Other jobs currently listed on the site include a liveried helper – responsible for getting the Queen’s horses ready for Royal events – and an operational support coordinator for the Royal Collection Trust. The advert for the cyber job states the job involves ‘delivering work that matters’ and ‘being a part of the professional business behind the monarchy’. The Queen (pictured during a zoom call) is looking to hire a cyber security expert to protect the Firm’s emails and Google searches from hackers The Royal Household (pictured) posted an advertisement for a Cyber Security Engineer, earning between £50,000 and £60,000 and working 37 and a half hours a week It adds: ‘Joining our Cyber Security team, you’ll have a vital role in delivering our Cyber Security and Resilience Strategy. ‘You’ll monitor our network and systems, identify potential security threats and lead on response activities. ‘Carrying out technical investigations, you’ll identify potential risks and impacts, and ensure controls are in place across our hardware and software to keep us cyber secure and resilient. ‘You’ll regularly review and evaluate our cyber security and response activities and working in close collaboration with...
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