Finding medicines that can kill cancer cells while leaving normal tissue unscathed is a Holy Grail of oncology research. In two new papers, scientists at UC San Francisco and Princeton University present complementary strategies to crack this problem with “smart” cell therapies – living medicines that remain inert unless triggered by combinations of proteins that only ever appear together in cancer cells. Biological aspects of this general approach have been explored for several years in the laboratory of Wendell Lim, PhD, and colleagues in the UCSF Cell Design Initiative and National Cancer Institute-sponsored Center for Synthetic Immunology. But the new work adds a powerful new dimension to this work by combining cutting-edge therapeutic cell engineering with advanced computational methods. For one paper, published Sept. 23, 2020, in s, members of Lim’s lab joined forces with the research group of computer scientist Olga G. Troyanskaya, PhD, of Princeton’s Lewis-Sigler Institute for Integrative Genomics and the Simons Foundation’s Flatiron Institute. Using a machine learning approach, the team analyzed massive databases of thousands of proteins found in both cancer and normal cells. They then combed through millions of possible protein combinations to assemble a catalog of combinations that could be used to precisely target only cancer cells while leaving normal ones alone. In another paper, published in Science on Nov. 27, 2020, Lim and colleagues then showed how this computationally derived protein data could be put to use to drive the design of effective and highly selective cell therapies for cancer. “Currently, most cancer treatments, including CAR T cells, are told ‘block this,’ or ‘kill this,’” said Lim, also professor and chair...
Laravel migration mechanism has a great function of seeding data. In this article, I will show random tips from my own experience, how to use seeding in real-life cases. Tip 1. Use updateOrCreate() to avoid double-seeding Imagine this seeder code, and imagine if for some reason this seeder would be launched more than once: Second attempt to run seeder would probably fail because of conflicting IDs. In other scenario, if you don’t specify IDs, then you may end up with too much data in the table, with repeating entries. To avoid that, do this: Some more details in my other article. Tip 2. Run only one Seeder class Some time ago I was quite surprised by how many people don’t know that you can specify a seeder class when running php artisan db:seed. This command above will launch everything listed in DatabaseSeeder.php file. But you can limit the launch to one exact seeder: Tip 3. Run Seeder Class From Migration Quite often you need to create a new DB table and immediately seed it with some data. But in production environment you can’t just run “artisan db:seed”, especially if you have automated deployment setup which involves only “artisan migrate” command. The trick is to launch a specific seeder from migration file itself. Tip 4. Seeder Factory with Relationship: Use Parent’s Factory If you use Factories for your seeds, how do you set up relationships between two models? For example, you need to seed 10 companies and 10 contacts within those companies? Here’s how database/factories/CompanyFactory.php may look like: See how company_id field is filled in? With another factory. There’s also another, perhaps...
This guest column is by Prateek Saxena, Managing Director, AppInventiv Mobile app development has become the most crucial task, which has a direct impact on setting up of different companies as a startup, and also regarding their marketing and popularity. Of course, nobody wants an insipid and monotonous app which is identical to other apps in the market. Here I am going to present the voyage mobile app developer goes through. In the current scenario, as a technical or nontechnical startup founder, if you are thinking about developing a mobile application think again! According to a report from WMC forum, just in October 2012, there were 43813 new apps launched in iOS app store alone i.e. 1400 new apps per day. Can you imagine where those numbers could reach if you include Android app store as well in 2016? But many of them were completely fiasco. Developing a mobile app is a herculean task. Even to reach the app store you have to cross so many hurdles. Here are some unfeasible challenges faced by mobile app developer as a startup founder. 1. App Discovery The fundamental aim of developing an app is to make life simple, productive and pleasant. Keeping it in mind, creating an app which gets noticed is a grueling task. There are a way more good apps than there are successful ones, and that’s because many of the good ones don’t get investment. App discovery is extremely concerned with who are your users, what type of service they are expecting, their financial background and many others factors. Make sure while choosing developer team, it must be...
By Matt Huntington Three months into my first job out of college, as a web developer at a financial reporting company, I wiped out every single one of my company’s client records in one command. I had uploaded a script meant to eliminate one client, but quickly realized that it removed all of them and I couldn’t get the records back. (This was in the early 2000s, when it was less common to work locally before sending code to your live website.) I went into full-on crisis mode and started getting my resume ready, resigned to the fact that I was going to be fired. I was even Googling to see if I could be sued for what I had done. As a web developer, you’re going to fail — often, and sometimes in huge ways — whether you’re a newbie or a veteran. Thankfully, a tech manager saved the day by telling me about the company’s nightly database backup and we quickly fixed most of the problem. But until that moment, I was sweating bullets.As a web developer, you’re going to fail — often, and sometimes in huge ways — whether you’re a newbie or a veteran (for example, see this recent mishap at Amazon’s web hosting service S3, in which a typo took down massive services like Trello and Quora). But messing up doesn’t have to be stressful. In fact, when it does happen, staying calm is key because panic can cloud your judgement and force you to make rash decisions.If you understand how to diagnose a problem, learn from your mistakes, and remember that this happens...
What happened in the Colonial Pipeline ransomware attack Colonial Pipeline, the operator of a major pipeline system that transports fuel across the East Coast said it had been victimized by a ransomware attack and had halted all pipeline operations to deal with the threat. It may seem too late to fill the position now, but Colonial Pipeline, the target of the biggest pipeline hack in history, began searching for a cyber-security manager nearly two months ago. Colonial Pipeline, a Georgia-based oil company, sought someone to manage a team of security experts in order to “develop, validate and maintain an incident response plan and processes to address potential threats.” Job requirements included a bachelor’s degree in computer science, information security or a related field, according to an on Colonial’s website. The job posting also appeared on search sites such as Indeed, ZipRecruiter and GlassDoor. A spokesperson for the company told FOX Business that the position – which has been open for more than 30 days – was not created as a result of the ransomware attack and is part of a broader initiative by the company to “continue building our current cybersecurity team.” “We have several positions open as part of our longer-term growth strategy around talent, as we are constantly recruiting top-tier talent across all functional areas of our business,” the spokesperson added. The ransomware attack crippled North America’s biggest fuel pipeline late last week, cutting off almost half of the gasoline and diesel burned on the nation’s East Coast. Gas stations across several states have run out of fuel amid panic-buying and a lack of supplies. The average...
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